An automatic optimization system for semiconductor devices has been built-up by fully interfacing an optimizer and a device-analysis code supplemented with sensitivity analysis. The device-analysis code is thought of as a part of a pipeline of simulators. The latters are regarded as subprocesses by the optimizer, which controls their I/O stream. The action of the pipeline is iterated until the optimum set of design parameters is determined. An important feature of the system is that all the derivatives required in the sensitivity analysis are calculated analytically, this providing a substantial improvement in both the numerical accuracy and computational efficiency, and making the scheme attractive from the application standpoint. A few examples of optimization of MOS devices are shown and the performance is reported, indicating that a system of this kind can usefully be exploited in a design environment.